Which type of Hemophilia is caused by a deficiency in Factor IX?

Hemophilia B is specifically linked to a deficiency in Factor IX, which is necessary for the blood coagulation process. Individuals with Hemophilia B often experience prolonged bleeding or difficulty in blood clotting because the lack of this clotting factor impairs the formation of fibrin clots.

In contrast, Hemophilia A results from a deficiency in Factor VIII, which is different from Factor IX. Von Willebrand disease is a separate condition that involves a deficiency or dysfunction of von Willebrand factor, affecting platelet function and stability of Factor VIII. Factor V Leiden thrombophilia is unrelated to hemophilia and involves a mutation that increases the risk of clot formation due to abnormal Factor V.

Understanding the specific roles of these factors in the clotting cascade helps clarify why Hemophilia B, associated with Factor IX deficiency, leads to the symptoms and risks associated with this bleeding disorder.