Which syndrome presents with rocker bottom feet and clenched fists on ultrasound?

Edward's Syndrome, also known as Trisomy 18, is characterized by several distinctive physical features that can often be identified during an ultrasound scan. The presence of rocker bottom feet—where the soles of the feet are rounded with a prominent heel—and clenched fists are classic findings associated with this condition.

These features arise due to the developmental disruptions caused by the extra chromosome 18 in affected individuals. The clenched fists are often noted because the hands may be held in a tight grip, which is a result of neurological and muscular anomalies prevalent in this syndrome. The rocker bottom feet are a consequence of malformations in the foot's structure, leading to the characteristic shape.

In contrast, while Down Syndrome (Trisomy 21) and Turner Syndrome (a chromosomal disorder in females resulting from the complete or partial absence of one X chromosome) present with their own unique ultrasound findings, they do not typically feature both rocker bottom feet and clenched fists. Patau Syndrome (Trisomy 13) also has its own set of distinguishing markers, such as holoprosencephaly and cystic hygromas, but lacks the combination of symptoms specific to Edward's Syndrome.