Which syndrome is characterized by overgrowth and is NOT on the list of known overgrowth syndromes?

Marfan syndrome is recognized primarily for its association with connective tissue anomalies rather than being classified as an overgrowth syndrome. While individuals with Marfan syndrome can exhibit some features that might appear to indicate overgrowth, such as tall stature and long limbs, the defining characteristics of the syndrome relate to cardiovascular, skeletal, and ocular manifestations. These do not conform to the traditional definitions of overgrowth syndromes, which are more directly associated with excessive cellular proliferation and growth.

In contrast, the other options listed, including Pallister-Killian syndrome, Perlman syndrome, and Sotos syndrome, are well-documented overgrowth syndromes. These conditions are characterized by significant growth abnormalities and involve distinct genetic mutations that lead to excess tissue growth, distinguishing them from Marfan syndrome. This delineation helps clarify why Marfan syndrome is the correct choice in this context.