Which symptom is NOT typically associated with Koolen De Vries Syndrome?

Koolen De Vries Syndrome is characterized by a distinct set of symptoms and clinical features. Among the symptoms typically associated with this syndrome, progressive coarsening of facial features is not one of them. Instead, individuals with Koolen De Vries Syndrome generally present with a range of manifestations including severe intellectual disability, obesity, and various congenital malformations, such as cardiac defects, renal anomalies, or other structural changes.

The lack of coarsening of facial features is an important diagnostic criterion because many other conditions, particularly various syndromic disorders, display a progressive coarsening of features over time. The absence of this specific characteristic in Koolen De Vries Syndrome helps differentiate it from other syndromes where such a feature is prominent. The recognized symptoms emphasize the need for careful clinical assessment in diagnosing genetic conditions, as facial features often play an essential role in the identification of various syndromic presentations.