Which symptom is not typically associated with McCune-Albright syndrome?

Prepare for the American Board of Genetic Counseling Test. Engage with flashcards and multiple choice questions, each question comes with hints and explanations to enhance your knowledge. Get exam ready!

McCune-Albright syndrome is characterized by three main features: fibrous dysplasia of bone, café au lait spots, and endocrine abnormalities such as precocious puberty. Among these features, café au lait spots are distinct skin lesions that often present in large, irregular patches, while osteitis fibrosa cystica occurs due to excessive levels of parathyroid hormone and often accompanies the fibrous dysplasia.

Excess growth hormone, which leads to symptoms similar to acromegaly, is also not uncommon in this syndrome due to the various endocrine issues present. However, cleft palate is not typically listed as a symptom associated with McCune-Albright syndrome. Cleft palate is a congenital condition resulting from incomplete fusion of the maxillary processes and is not part of the classic triad of features exhibited by individuals with McCune-Albright syndrome. Thus, it is accurate to state that cleft palate is not associated with this syndrome.

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