Which of the following is a common symptom of Alagille Syndrome?

Prepare for the American Board of Genetic Counseling Test. Engage with flashcards and multiple choice questions, each question comes with hints and explanations to enhance your knowledge. Get exam ready!

Alagille syndrome is a genetic disorder that affects multiple systems in the body, particularly the liver, heart, and skeleton. One of the hallmark skeletal abnormalities associated with this condition is the presence of "butterfly vertebrae." This term refers to a specific shape of the vertebrae that resembles a butterfly, and it is a distinctive feature observed in many individuals with Alagille syndrome. It occurs due to the malformation of spinal vertebrae during development, which is part of the skeletal dysplasia seen in this syndrome.

In contrast, while hearing loss can sometimes be observed in individuals with Alagille syndrome, it is not a defining characteristic of the syndrome and may not be as prevalent or as specifically associated. Skin rashes, though they can occur in various conditions, are not specific to Alagille syndrome. Lastly, seizures are not a common feature associated with this syndrome, and their presence would suggest other underlying issues instead. Therefore, the presence of butterfly vertebrae is a defining symptom that aligns closely with the clinical presentation typically encountered in Alagille syndrome.

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