Which of the following features is commonly associated with Smith Magenis Syndrome?

Smith-Magenis Syndrome is characterized by several distinct features, and obesity is indeed one of the more prominent physical manifestations commonly associated with the condition. Individuals with Smith-Magenis Syndrome often exhibit a tendency towards obesity due to a combination of factors including behavioral aspects, such as overeating, and metabolic variations linked to the genetic mutations involved in this disorder. Additionally, this weight gain can often begin in early childhood.

The other features, while they have associations with other conditions, are not hallmark characteristics of Smith-Magenis Syndrome. For example, hypertelorism, which refers to an increased distance between the eyes, and downturned corners of the mouth may appear in various genetic syndromes but are not specifically common in Smith-Magenis Syndrome. Additionally, congenital heart defects can occur in many genetic conditions but are not specifically tied to Smith-Magenis Syndrome, making obesity a key distinguishing feature in this context.