Which condition often leads to testicular atrophy and self-injurious behavior?

Prepare for the American Board of Genetic Counseling Test. Engage with flashcards and multiple choice questions, each question comes with hints and explanations to enhance your knowledge. Get exam ready!

Lesch-Nyhan Syndrome is a genetic disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). This condition is characterized by a range of symptoms, including neurological and behavioral issues. One significant aspect of Lesch-Nyhan Syndrome is that it often leads to the development of testicular atrophy in males due to hormonal imbalances, particularly affecting testosterone levels, as the syndrome is linked to X-linked recessive inheritance and predominantly affects males.

Additionally, self-injurious behavior is a hallmark of this syndrome. Individuals with Lesch-Nyhan Syndrome may engage in behaviors such as biting their lips or fingers, which is thought to be associated with the neurobehavioral aspects of the condition. This combination of testicular atrophy and self-injurious behavior provides a clear connection to Lesch-Nyhan Syndrome, making it the condition that fits the description in the question.

In contrast, the other options listed do not have the same association with these specific symptoms. Hypertrophic cardiomyopathy primarily affects cardiac function, Noonan syndrome is characterized by distinct physical features and cardiovascular issues but does not typically involve testicular atrophy or self-injurious behaviors, and

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