What type of genetic condition typically leads to significant intellectual disability and other developmental issues in males?

MECP2 Duplication Syndrome is a genetic condition predominantly affecting males and is characterized by severe intellectual disability and a range of developmental issues. The condition arises due to the duplication of the MECP2 gene on the X chromosome, which is critical for normal brain development and function. Males are disproportionately affected because they have only one X chromosome, making them more susceptible to the effects of mutations or duplications in genes located on that chromosome.

Affected individuals often present with symptoms including loss of purposeful hand skills, gait abnormalities, seizures, and behavioral challenges. The significant impact on cognitive and physical development underscores the severity of the syndrome.

Balanced and Robertsonian translocations usually do not cause the severe intellectual and developmental deficits seen in MECP2 Duplication Syndrome. While unbalanced translocations can lead to developmental issues, the specific symptoms and severity of intellectual disability associated with MECP2 Duplication make it the more accurate answer in this context.