What percentage of individuals with MEN1 develop pancreatic NETs?

Individuals with Multiple Endocrine Neoplasia type 1 (MEN1) have a significant risk of developing pancreatic neuroendocrine tumors (NETs). Research indicates that approximately 20% to 80% of individuals with MEN1 will go on to develop these types of tumors. The wide range reflects variations in study populations and methods for screening and diagnosing pancreatic NETs in individuals with MEN1. Recognizing this range is crucial for healthcare providers to anticipate and monitor for potential development of pancreatic NETs in patients with MEN1, guiding appropriate surveillance strategies and management plans. This understanding emphasizes the importance of genetic counseling and the need for regular screening in susceptible individuals.