What is the typical onset age for Leber's Hereditary Optic Neuropathy (LHON)?

Leber's Hereditary Optic Neuropathy (LHON) typically presents in individuals during their teens to 20s. This condition is often characterized by the sudden loss of vision due to optic nerve damage, and the age range of onset corresponds with a peak incidence in young adults. The fact that LHON's onset is commonly seen in this demographic is associated with the mitochondrial mutations that cause the disorder, as these mutations can become more pronounced around this age.

While some genetic conditions do have early onset presentations, such as in childhood or at birth, LHON is notably not one of them, making the age range of teens to 20s the most accurate characterization of its typical onset. This understanding is vital for genetic counselors when assessing family histories and counseling affected individuals or at-risk relatives.