What is the estimated risk of developing colorectal cancer by age 60 for individuals with MUTYH Associated Polyposis?

Individuals with MUTYH Associated Polyposis (MAP) have a significantly elevated risk of developing colorectal cancer. MUTYH is a DNA repair gene, and mutations in this gene are associated with the development of multiple adenomatous polyps, which can progress to colorectal cancer. The estimated risk of developing colorectal cancer by age 60 for individuals with this condition is indeed around 90%. This high percentage reflects the severity and progressive nature of the disease, highlighting the necessity for early surveillance and intervention in affected individuals.

The other options present lower risk percentages that do not accurately represent the current understanding of MUTYH-associated colorectal cancer risk. Although various studies have examined the risks based on family and personal medical history, the consensus indicates that 90% risk is the most accurate estimate for this specific genetic condition.