What is the carrier frequency for Canavan disease in Ashkenazi Jews?

The carrier frequency for Canavan disease among Ashkenazi Jews is well-established at approximately 1 in 40. This high prevalence is attributed to the historical founder effect within this population, where a limited number of ancestors contributed to the genetic makeup of the group. As a result, certain genetic disorders, including Canavan disease, are more common compared to other populations. Understanding carrier frequencies is critical in genetic counseling, especially when advising families on the risks of hereditary conditions. In the case of Ashkenazi Jews, being aware of this frequency can guide genetic testing and help identify carriers within families.