What is a notable sign of Galactosemia in infants?

The notable sign of Galactosemia in infants is cataracts. Galactosemia is a metabolic disorder resulting from the body's inability to break down galactose, a sugar found in milk and dairy products. The accumulation of galactose in the body can lead to various complications, one of which is the development of cataracts, often detectable in infants as early as a few weeks or months after birth.

Cataracts in infants with Galactosemia are specifically due to the toxic effects of accumulating galactose, which can affect the lens of the eye. This is a significant clinical feature, as early detection through newborn screening can lead to dietary interventions that help prevent further complications associated with the disorder.

The other options do not specifically correlate with Galactosemia. Persistent fevers may indicate various infections or other underlying conditions, low blood pressure does not relate to this metabolic disorder, and excessive weight gain is not typical for infants with Galactosemia, who often do not thrive well due to feeding difficulties and metabolic imbalances. Thus, cataracts stand out as a key indicator of this condition in infants.