What is a common complication in individuals with WAGR syndrome linked to the deletion of the WT1 gene?

In the context of WAGR syndrome, the deletion of the WT1 gene is notably associated with several complications, one of which is intellectual disability. WAGR syndrome is characterized by Wilms tumor (a type of kidney cancer), Aniridia (absence of the iris), Genitourinary abnormalities, and Range of developmental delays, including cognitive impairments typically manifesting as intellectual disabilities.

The WT1 gene is crucial for normal development, especially in the formation of kidneys and gonads, as well as in the brain, which can explain the cognitive and developmental challenges seen in affected individuals. While the other options listed (obesity, seizures, and hearing loss) can occur in various genetic conditions or in the general population, they are not classical complications directly associated with WAGR syndrome stemming from the loss of the WT1 gene. Hence, the intellectual disability is the most pertinent complication linked to the genetic changes in WAGR syndrome.