Leber's Hereditary Optic Neuropathy has a higher prevalence in which gender?

Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited condition that primarily affects the optic nerve, leading to vision loss. Research has shown that LHON has a significantly higher prevalence in males compared to females. The reason for this gender disparity is not fully understood, but it is believed that protective factors in females, such as the presence of two X chromosomes, may play a role in reducing the severity and penetrance of the disease in women.

In contrast, the other answer choices do not align with the established understanding of LHON’s demographic trends. While females and transgender individuals can be affected, their prevalence rates are lower than those of males. Therefore, acknowledging the higher prevalence in males is crucial for understanding the genetic and epidemiological aspects of Leber's Hereditary Optic Neuropathy.