Fragile X Syndrome most commonly leads to what characteristic physical feature?

Fragile X Syndrome is a genetic condition that often results in distinct physical features, with a long face being one of the most characteristic traits. Individuals with this syndrome typically display a long, narrow facial structure, which is due to the effects of the genetic mutation on the FMR1 gene located on the X chromosome. This long facial appearance can be a prominent indicator of the syndrome and is often observed alongside other features such as prominent ears and a prominent jaw.

In contrast, while some of the other options might occur in different contexts or conditions, they are not closely associated with Fragile X Syndrome specifically. Short stature, large hands, and facial asymmetry can sometimes occur in various genetic and developmental disorders, yet they are not defining features of Fragile X. Therefore, the long face is the most prominent and recognizable physical characteristic associated with individuals who have Fragile X Syndrome, making it the correct answer.