Aicardi Syndrome primarily affects which gender?

Aicardi Syndrome is a rare genetic condition that predominantly affects females. This syndrome is characterized by the combination of agenesis of the corpus callosum, chorioretinal abnormalities, and seizures, among other features. The reason this condition primarily affects females is believed to be linked to its X-linked genetic pattern. Given that females have two X chromosomes, they may have a higher likelihood of manifesting the symptoms of the disorder if there is a mutation on one of their X chromosomes. In contrast, males typically have one X and one Y chromosome; if they inherit a mutated version of the gene associated with Aicardi Syndrome on their single X chromosome, it can lead to more severe manifestations or, in many cases, can be lethal. Thus, the skewed distribution of Aicardi Syndrome towards females is largely attributed to the genetic mechanisms underlying the condition.