A finding of 2-3 syndactyly might prompt consideration of which syndrome?

The presence of 2-3 syndactyly, which refers to the fusion of the second and third fingers or toes, is notably associated with the Syndrome of Laterality (SLO). This condition involves a disruption in the normal development of the limbs and is characterized by various limb anomalies, including syndactyly. While syndactyly can occur in several genetic conditions, its specific connection to SLO highlights the importance of understanding the morphological features that may suggest underlying syndromic associations.

Syndactyly itself is not a hallmark feature of the other conditions listed. For instance, Turner syndrome primarily presents with short stature, gonadal dysgenesis, and may include cardiac defects, but does not typically involve limb anomalies like syndactyly. Neurofibromatosis is characterized by café-au-lait spots, neurofibromas, and other systemic features, rather than syndactyly as a defining trait. Marfan syndrome is predominantly associated with skeletal, cardiovascular, and ocular features, such as tall stature and lens dislocation, and does not frequently include syndactyly as a clinical manifestation.

Therefore, the identification of 2-3 syndactyly ideally suggests further investigation into the possibility of the Syndrome of Laterality, making it the most